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Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA Abstract A defined spatial and temporal control of induction of toxicity in response to external ionizing radiation such as X-rays has unique clinical benefits over conventional systems such as passive drug delivery or its activation. Here, we have combined X-rays with …

Development of radiation-triggered phosphor platform for localized activation in combinatory cancer treatment (July, 2021) Read More »

Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV-2), a single-stranded RNA virus with largest genomes (∼ 29,800 bases) of all viruses, causes the infectious disease, COVID-19. SARS-CoV-2 is a zoonotic betacoronavirus transmitted through airborne and fecal-oral routes infecting nasal, lung, and intestinal …

Inhibition of pseudo SARS-CoV-2 binding activity of a anti-cancer polypharmacological agent analogs (July, 2021) Read More »

Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA Abstract We report the advances of a cloud-based software utilizing advanced algorithms to identify the molecular cancer drivers and its signal transduction. To test, a classifier based on the NFκB signaling pathway gene expression profiles that predicts the clinical therapeutic response …

Cloud-based biological domain knowledge derived gene expression classifier to predict the cancer clinical outcome (July, 2021) Read More »

Modified Sugar a new weapon against COVID-19 2-Deoxy-D-Glucose 2DG, an Adjuvant in COVID-19 Therapy Arsenal. Dr. Rao Papineni lab was the earliest proponent of using 2-DG for polypharmacological action (in lay terms, multiple drug actions) against COVID-19. The hypothesis in this seminal publication (https://www.tandfonline.com/loi/irab20) states that polypharmacological effects of 2-DG on the virally-infected lung cells …

Modified Sugar a new weapon against COVID-19 (May, 2021) Read More »

Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains in radiation therapy by specifically delivering radiation to tumors that can be well assessed in terms of dosimetry and imaging. Dosimetry in external beam radiation therapy is standard practice. This is not the case, however, in RPT. This NRG (acronym formed from …

Overcoming Barriers to Radiopharmaceutical Therapy (RPT): An Overview From the NRG-NCI Working Group on Dosimetry of Radiopharmaceutical Therapy (March, 2021) Read More »

Highlights • The cardiac specific mAb receptors are bound to SPION-PEG micelle through covalent bonding. • The engineered cardiac specific nanoprobe when incubated with the MSCs of stromal vascular fraction yields positively selected cells through the magnetic assorted cell sorting column. • Myocardial infarction is introduced in the healthy mice using isoproterenol through the intraperitoneal …

Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI (February 2021) Read More »

Abstract COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease and is the major cause of deaths worldwide. The clinical complexities (inflammation, cytokine storm, and multi-organ dysfunction) associated with COVID-19 poses constraints to effective management of critically ill COVID-19 patients. Low dose radiation therapy (LDRT) has been evaluated as a …

A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management (October, 2020) Read More »