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Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA Abstract We report the advances of a cloud-based software utilizing advanced algorithms to identify the molecular cancer drivers and its signal transduction. To test, a classifier based on the NFκB signaling pathway gene expression profiles that predicts the clinical therapeutic response …

Cloud-based biological domain knowledge derived gene expression classifier to predict the cancer clinical outcome (July, 2021) Read More »

Modified Sugar a new weapon against COVID-19 2-Deoxy-D-Glucose 2DG, an Adjuvant in COVID-19 Therapy Arsenal. Dr. Rao Papineni lab was the earliest proponent of using 2-DG for polypharmacological action (in lay terms, multiple drug actions) against COVID-19. The hypothesis in this seminal publication (https://www.tandfonline.com/loi/irab20) states that polypharmacological effects of 2-DG on the virally-infected lung cells …

Modified Sugar a new weapon against COVID-19 (May, 2021) Read More »

Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains in radiation therapy by specifically delivering radiation to tumors that can be well assessed in terms of dosimetry and imaging. Dosimetry in external beam radiation therapy is standard practice. This is not the case, however, in RPT. This NRG (acronym formed from …

Overcoming Barriers to Radiopharmaceutical Therapy (RPT): An Overview From the NRG-NCI Working Group on Dosimetry of Radiopharmaceutical Therapy (March, 2021) Read More »

Highlights • The cardiac specific mAb receptors are bound to SPION-PEG micelle through covalent bonding. • The engineered cardiac specific nanoprobe when incubated with the MSCs of stromal vascular fraction yields positively selected cells through the magnetic assorted cell sorting column. • Myocardial infarction is introduced in the healthy mice using isoproterenol through the intraperitoneal …

Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI (February 2021) Read More »

Abstract COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease and is the major cause of deaths worldwide. The clinical complexities (inflammation, cytokine storm, and multi-organ dysfunction) associated with COVID-19 poses constraints to effective management of critically ill COVID-19 patients. Low dose radiation therapy (LDRT) has been evaluated as a …

A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management (October, 2020) Read More »

Virtual International Transdisciplinary Conference (VITC-2020) organized by Department of Physics, School of Advanced Sciences, Vellore Institute of Technology, Vellore – 632 014, TN, India Date: 26th – 28th August 2020 Inauguration Chief Guest : Prof. V. Ramgopal Rao, Director, Indian Institute of Technology-Delhi, India Guest of Honour : Prof. Giuseppe Maruccio, Professor, University of Salento, …

Virtual International Transdisciplinary Conference (VITC-2020) (August 2020) Read More »

Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA Abstract Radiation-produced quasi-free electrons (i.e., low energy electrons in solutions) causes DNA damage. However, there are no evidence that radiation-produced partially solvated electrons (i.e., presolvated or, prehydrated electrons) and fully solvated electrons (i.e., aqueous or solvated electrons) cause strand breaks. However, …

Multiple chemical action cancer therapeutics (April, 2020) Read More »

Abstract This article presents the results of a workshop held in Stirling, Scotland in June 2018, called to examine critically the effects of low-dose ionising radiation on the ecosphere. The meeting brought together participants from the fields of low- and high-dose radiobiology and those working in radioecology to discuss the effects that low doses of …

The tubercular badger and the uncertain curve:- The need for a multiple stressor approach in environmental radiation protection (January, 2019) Read More »

For development of I-PARTS integrated platform for anti-cancer radiation therapeutics screening The award was given for the development of anti-cancer agents and radiation modulators screening devices. PACT and Health of Branford, CT, US has been awarded Phase II Small Business Innovation Research (SBIR) two-year contract by National Cancer Institute (NCI) for the development of I-PARTS …

PACT and Health bags Phase II Small Business Innovation Research award (September, 2019) Read More »

RRS Vodcast interviewing Dr. Rao Papineni on cancer therapy and radiobiophotonics.